Vascular Origin of a Soluble Truncated Form of the Hepatocyte Growth Factor Receptor (c-met)
نویسندگان
چکیده
منابع مشابه
Vascular origin of a soluble truncated form of the hepatocyte growth factor receptor (c-met).
Hepatocyte growth factor (scatter factor) is an angiogenic growth factor that binds to its cellular transmembrane receptor, c-met. Both HGF and c-met are expressed by vascular smooth muscle and endothelial cells, where HGF may exert autocrine and paracrine effects. We have found that human aortic smooth muscle cells (HASMCs) and human umbilical vein endothelial cells (HUVECs) release a soluble,...
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Abstract Background and objectives: C-Met is a proto-oncogene that encodes a protein known as hepatocyte growth factor receptor (HGFR). The HGF receptor possesses tyrosine -kinase activity and it is essential for embryonic development, wound healing and cancer. Many proteins are proteolytically released from the surface by a process known as ectodomain shedding. Shedding occurs under normal phy...
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It has recently become evident that elevation of reticulocytes in the circulation of several species, including humans, leads to the formation of a noncellular transferrin receptor (TFR). In humans, the majority of the released receptor is in truncated form (Shih et al: J Biol Chem 265:19077, 1990). In other species (sheep, rat, chicken) the receptor is associated with a vesicle (exosome) and i...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2002
ISSN: 0009-7330,1524-4571
DOI: 10.1161/hh0102.102756